THE CHEMIST WHO FOUND STRUCTURE OF PENCILLIN AND INSULIN
Though born in the twentieth century, Dorothy Crowfoot Hodgkin had a typical late-nineteenth century upbringing. She was born in Cairo, Egypt, then a British colony. When Hodgkin was four, the family was back in England and World War I broke out. The parents returned to Egypt, leaving the children with family and governesses for four years. Hodgkin found an interest in chemistry and crystals, a popular hobby for women of leisure in the 1800s. But on her sixteenth birthday, she received a book by William Henry Bragg (a Nobelist in physics) about using x-rays to analyze crystals. She had found her life's work.
When Hodgkin graduated from Oxford in 1932, jobs were scarce. She found a position in an x-ray crystallography lab studying biological crystals. This technique helped tease out the structure of molecules. Though diagnosed at age 24 with rheumatoid arthritis, she became one of the most skilled crystallographers of her time. In Cambridge and later at Oxford, she always chose projects that no one else thought quite possible. She ran into Ernst Chain one day, who was beaming from his recent animal trials of penicillin. It took four years, but she cracked penicillin's complex and misleading structure in 1946. That knowledge would help manufacturers create semisynthetic penicillins. Ten years later she announced the structure of vitamin B12, and in 1964 won the Nobel Prize in chemistry. In 1969, she finally solved the puzzle of the structure of insulin.